Micellar drug nanocarriers and biomembranes: how do they interact?

Micellar drug nanocarriers and biomembranes: how do they interact?

Pluronic based formulations are among the most successful nanomedicines and block-copolymer micelles including drugs that are undergoing phase I/II studies as anticancer agents. Using coarse-grained models, molecular dynamics simulations of large-scale systems, modeling Pluronic micelles interacting with DPPC lipid bilayers, on the μs timescale have been performed. Simulations show, in agreemen...

Cell phone and brain: how do they interact?

How tubular aggregates interact with biomembranes: wrapping, fusion and pearling.

How soft tubular aggregates interact with biomembranes is crucial for understanding the formation of membrane tubes connecting two eukaryotic cells, which are initially created from one cell and then connect with the other. On the other hand, recent experiments have shown that tubular polymersomes display different cellular internalization kinetics in their biomedical applications compared with...

Universal Grammar and Chaos/Complexity Theory: Where Do They Meet And Where Do They Cross?

  Abstract The present study begins by sketching "Chaos/Complexity Theory" (C/CT) and its applica-tion to the nature of language and language acquisition. Then, the theory of "Universal Grammar" (UG) is explicated with an eye to C/CT. Firstly, it is revealed that CCT may or may not be allied with a theory of language acquisition that takes UG as the initial state of language acquisition for ...

How Many are they and How Do they live?

This paper attempts to define the common people of India in terms of levels of consumption and examines their socio-economic profile in different periods of time since the early 1990s with a view to assessing how the economic growth process has impacted on their lives. The findings should worry everyone. Despite high growth, more than three-fourths of Indians are poor and vulnerable with a leve...